孔晓颖-检验医学院

教育经历

2007/09-2012/06中国海洋大学，海洋生物学，博士指导老师：刘万顺教授

2003/09-2007/06烟台大学，生物技术，学士

工作经历

2012/09-2022/02青岛农业大学，药学院，讲师

2022/03-2024/09青岛农业大学，药学院，副教授

2024/11-至今青岛大学，青岛医学院，副教授

访学经历

2019/06-2020/01到韩国釜庆大学Park教授课题组访学并一直保持交流合作。

主要学术任职

2024-至今担任中国医学装备协会病理装备分会委员

2024-至今担任山东生物医学工程学会生物材料专业委员会委员

2024-至今担任中华志愿者协会中西医结合专家志愿者委员会再生医学全国专业组委员

2025-至今担任Aging&Disease国际杂志青年编委

研究方向

智能纳米药物材料的开发与多疾病模型免疫调控相关性研究。申请者在光疗、离子干扰、化学动力智能纳
米药物平台开发基础上，着手开展智能纳米药物和多疾病模型免疫调控相关性研究，对确定免疫系统活化在非药
物治疗策略中的地位具有重要研究价值，对优化临床多疾病模型的智能纳米药物开发方案也具有积极的临床意义；
（2）智能纳米药物用于多疾病模型创面修复。申请者提出通过智能纳米药物与水凝胶相结合的策略，通过光疗
、离子干扰、化学动力三维调控的模式，实现高效抗生物膜和自体免疫调控，调控多种疾病模型的创面愈合。
荣誉
2023第九届山东省“互联网+”大学生创新创业大赛省级银奖指导教师
2023 “建行杯”第九届山东省大学生科技创新大赛省级三等奖指导教师
2023青岛农业大学优秀学士学位论文指导教师
2022全国大学生生命科学(CULSC)竞赛国家级三等奖指导教师
2022山东省第十三届“挑战杯”山东省大学生创业计划竞赛省级银奖指导教师
2022第八届山东省“互联网+”大学生创新创业大赛省级铜奖指导教师

2020 “创业枣庄共赢未来”高层次人才创业大赛，优秀奖

2018山东省第五届“超星杯”高校青年教师教学比赛，优秀奖

2018青岛农业大学优秀学士学位论文指导教师

2017-2018青岛农业大学“长和国际奖教金”

2017青岛农业大学第三届青年教师教学比赛，二等奖

2017青岛农业大学优秀学术导师

2016-2017青岛农业大学“长和国际奖教金”

发表论文与著作(#共同一作，*通讯作者)

迄今为止，已在生物医学相关领域的国际著名期刊发表SCI论文32篇，以第一作者/通讯作者发表28篇SCI论文，

代表性论文(#equal contribution, *corresponding author):

[1]Shi J, Han W, Wang J,Kong X*.Anti-tumor strategies targeting nutritional deprivation: Challenges and opportunities.Adv. Mater.,2025, 202415550.(自然指数期刊,中科院大类一区Top,IF=27.4，他引：0)

[2]Zhang F , Wang T, Wang W, Lv Y, Qu Y, Liu D, Sun X,Kong X*, Wang C*, Shi J*.ZnO colludes with C. acnes in healing delay and Scar hyperplasia by barrier destruction.J Nanobiotechnol., 2025, 23: 404.(中科院大类一区Top, IF=10.6，他引：0)

[3]Ding M#, Chen H#, Guimarães CF, Reis RL,Wu L, Zhang F, Lv Y, Wang T, Zhou Q*, Shi J*,Kong X*. Activated Immune System Determines In Vivo Anti-Tumor Effect of Phototherapy by Inhibiting Cancer-Associated Fibroblasts.Adv. Funct. Mater., 2024, 2315551.(自然指数期刊,中科院大类一区Top, IF=18.5,该工作入选Angewandte Chemie International Edition期刊Hot Topic: Tumors and Cancer专题, https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1521-3773. hottopic-cancer-tumors，他引：5)

[4] Wang T, Zhang F, Guimarães CF, Reis RL, Lv Y, Qu Y, Liu D, Zhou Q,*Kong X*,Shi J*. Zn/Cu Bi-Single-Atom Nanoplatform: HexagonalAnti-Tumor Warrior by ROS Amplification for DOX Resistance Reversal and Immune Activation.Adv. Funct. Mater.,2024, 2410962.(自然指数期刊,中科院大类一区Top, IF=18.5，他引：2)

[5] Yan J, Chen H, Guimarães CF, Reis RL, Zhu Z, Wang T, Zhang F, Lv Y, Zhou Q*,Kong X*, Shi J*. Cu⁺/Ca²⁺ dual-overload strategy assisted by metabolic-symbiotic-destruction for tumor apoptosis and tumor immune activation.Adv. Funct. Mater.,2024,2403245.(自然指数期刊,中科院大类一区Top,IF=18.5，他引：3)

[6] Chen H, Song J, Wang Y, Wang T, Zhang F, Lv Y, Liu Z, Fu J*,Kong X*. "Triple-Hop" Nano-Bomb Combining CDT, PDT and Immunetherapy for NIR-Triggered Cancer Therapy.Chem. Eng. J,2024, 481: 148268. (中科院大类一区Top, IF=15.1，他引：11)

[7] Jiang Y, Shao K, Zhang F, Wang T, Han L*,Kong X*, Shi J*. "Block and attack" strategy for tumor therapy through ZnO₂/siRNA/NIR-mediating Zn²⁺-overload and amplified oxidative stress.Aggregate,2023, 4: e321. (中科院大类一区Top, IF=18.8，他引：6)

[8] Song J#, Chen H#, Lv Y, Yang W, Zhang F, Wang T, Liu D, Qu Y, Han L*, Fu J*,Kong X*. CuO₂-assisting-Zn single atom hybrid nanozymes for biofilm-infected wound healing. Chem. Eng. J,2023, 474: 145706. (中科院大类一区Top，IF=15.1，他引：24)

[9] Ding M, Chen H, Wang T, Wu L, Shao K, Han L*,Kong X*, Shi J*. “Cocktail” anti-tumor strategy through enhanced antigen exposure with photothermal/chemodynamic therapy. Chem. Eng. J,2023, 456: 141091. (中科院大类一区Top，IF=15.1，他引：5)

[10] Chen H, Wu L, Wang T, Zhang F, Song J, Fu J*,Kong X*, Shi J*. PTT/ PDT-induced microbial apoptosis and wound healing depend on immune activation and macrophage phenotype transformation. Acta Biomater.,2023, 167: 489-505.(中科院大类一区, IF=9.7，他引：36)

[11]Kong X#, Chen H#, Li F, Zhang F, Jiang Y, Song J, Sun Y*, Zhao B*, Shi J*. Three-dimension chitosan hydrogel loading melanin composite nanoparticles for wound healing by anti-bacteria, immune activation and macrophage autophagy promotion. Int. J Biol. Macromol.,2023, 237: 124176. (中科院大类一区，IF=8.2，他引：17)

[12] Ge G, Wu L, Zhang F, Wang T, Han L*,Kong X*, Shi J*. Na2S2O4@Co-metal organic framework (ZIF-67) @glucose oxidase for biofilm-infecting wound healing with immune activation. Int. J Biol. Macromol.,2023, 226: 1533-1546. (中科院大类一区，IF=8.2，他引：18)

[13] Jiang Y, Meng W, Wu L, Shao K, Wang L, Ding M, Shi J*,Kong X*. Image-guided TME-improving nano-platform for Ca²⁺signal disturbance and enhanced tumor PDT.Adv. Healthc. Mater.,2021, 10(19): 2100789. (中科院大类二区Top, IF=10.0，他引：46)

[14]Jiang Y, Xu J, Lin Q, Song J, Sheng M, Lee J, ShiJ*,Kong X*, Tan Y*. pH-Activated Scallop-Type Nanoenzymes for Oxidative Stress Amplification and Photothermal Enhancement of Antibacterial and Antibiofilm Effect.ACS Appl. Mater. Interfaces,2023, 15(41): 47866-47879.(中科院大类二区, IF=9.5，他引：17)

（其中中科院一区论文11篇，二区论文11篇），累积影响因子超过283。论文被正面引用近400次。

[15] Jiang Y, Chen H, Wang T, Zhang F, Shi J*,KongX*, Chen W*.Dendritic Cu²⁺-Doped Ca₂SiO₄Nanosphere for Cancer Therapy via Double Ion Interference.ACS Appl. Nano Mater.,2022, 5(9): 13069-13077.(中科院大类二区, IF=5.9，他引：13)

[16] Yan J, Shao K, Wu L, Hu J, Man M, Li X,KongX*, Shi J*.Upconversion-nanoparticle-based smart drug-delivery platforms for multimodal imaging-guided cancer therapies.ACS Appl. Nano Mater.,2022,5(10): 15473-15487. (中科院大类二区, IF=5.9，他引：7)

[17]Ding M#,KongX#,ChenW,YanL,HuangH,LvZ,JiangP,MuA,HuangC,ShiJ. Efficient starvation therapy with three-pathway blocking in combination with PTT/CDT for TME reversal and tumor apoptosis.J Ind. Eng. Chem.,2022, 110: 456-470.(中科院大类二区, IF=6.1，他引：9)

[18]Jiang Y, Tan Y, Xiao K, Li X, Shao K, Song J,Kong X*, Shi J*. pH-Regulating nanoplatform for the “double channel chase” of tumor cells by the synergistic cascade between chlorine treatment and methionine-depletion starvation therapy.ACS Appl. Mater. Interfaces, 2021, 13, 54690-54705.(中科院大类二区, IF=9.5，他引：15)

[19]Ding M, Shao K, Wu L, Jiang Y, Cheng B, Wang L, Shi J*, Kong X*. A NO/ROS/RNS cascaded-releasing nano-platform for gas/PDT/PTT/immunotherapy of tumors.Biomater. Sci.,2021, 9: 5824.(中科院二区, IF=6.6，他引：48)

[20] Yan J, Meng W, Shan H, Zhang X, Zou L, Wang L*, Shi J*,KongX*. Melanin Nanoparticles Combined with CaO₂Nanoparticles for Image-Guided Tumor Microenvironment-Responsive Multimodal Therapy.ACS Appl. Nano Mater.,2021,4(2): 1351-1363.(中科院大类二区, IF=5.9，他引：22)

[21] Yan J, Ji Y, Yang M, Fu J, Shan H, Wang L, Zhang L, Xiao J,KongX*,Shi J*. C60-Decorated Melanin Nanoparticles Conjugated with Hyaluronic Acid for Synergistic Theranostic and Immunotherapy of Tumors under near-Infrared Excitation.ACS Appl. Nano Mater.,2020,3: 8817-8828.(中科院大类二区, IF=5.9，他引：21)

[22]Kong X, Fu J, Shao K, Wang L, Lan X, Shi J*. Biomimetic hydrogel for rapid and scar-free healing of skin wounds inspired by the healing process of oral mucosa. Acta Biomater.,2019, 100, 255-269. (中科院大类一区，IF=9.7，他引：75)

[23]Dong Y, Zhang C, Yang M, Fu J, Shan H, Wang L, Liu Z*, Shi J*,KongX*. Ion-Excited Mechanically Active Self-Assembling Membranes for Rapid Wound Healing.ACS Appl. Bio Mater.,2021,4(1):605-619.(IF=4.7)

[24]KongX, Houzong R, Fu J, Shao K, Wang L, Ma Y, Shi J*. Application of a novel thermo-sensitive injectable hydrogel in therapy in situ for drug accurate controlled release.J Biomed. Mater. Res. B,2020,108B:3200-3216.(中科院三区，IF=3.4，他引：13)

[25]Kong X,Kong C, Wen S, Shi J*. The use of heparin, bFGF, and VEGF 145 grafted acellular vascular scaffold in small diameter vascular graft.J Biomed. Mater. Res. B,2019,107(3): 672-679.(中科院三区IF=3.4，他引：18)

[26]Kong X¹*, Xu W²*, Zhang C, Kong W. Chitosan temperature-sensitive gel loaded with drug micropheres has excellent effeciveness, biocompatibility and safety as an ophthalmic drug delivery system.Exp. Ther. Med., 2018, 15: 1442-1448.(中科院四区IF=2.7，他引：34)

[27]Kong X*, Xu W. Biodegradation and biocompatibility of a degradable chitosan vascular prosthesis.Int. J Clin. Exp. Med., 8(3)(2015), 3498-3505.(中科院四区, IF=1.2，他引：10)

[28]Kong X, Han B, Wang H, Li H, Xu W, Liu W*. Mechanical Properties of Biodegradable Small-Diameter Chitosan Artificial Vascular Prosthesis.J Biomed. Mater. Res. A, 2012, 100A(8): 1938-1945.(中科院二区, IF=4.9，他引：18)

[28]Kong X, Han B, Wang H, Li H, Liang Y, Shao K, Liu W*. New Biodegradable Small-Diameter Artificial Vascular Prosthesis: A Feasibility Study.J Biomed. Mater. Res. A, 2012, 100A(6): 1494-1504.(中科院二区, IF=4.9，他引：21)

主持或参与的基金项目(总经费：107万)

授权/申请专利与成果转化

1.孔晓颖，师进生，曲郸。一种多功能生物滤膜及其的制备方法，批准年份：2020，专利号：ZL201710259080.6.

2.徐文华，孔晓颖，一种温敏溶胶的制备方法，批准年份：2017，专利号：ZL 2015 10358804.3

3.刘万顺，韩宝芹，孔晓颖，潘学理。一种多糖人工血管及其制备方法和应用，批准年份：2013，专利号：ZL 2010 10273913.2

4.李育强，王晓丽，王南南，孔晓颖，吕鑫，智倩倩。防蓝光眼镜基片和防蓝光抗疲劳眼镜，申请年份：2018，申请号：CN201810563871 .2

5.谭玉龙，徐嘉曼，师进生，孔晓颖，姜玉萍。一种多功能级联纳米酶、其制备方法及应用，申请年份：2022，申请号：CN202211388330 .3

6.师进生，孙钦星，王丽丽，孔晓颖。一种用于水体养殖无氮陶粒缓释肥的制备，申请年份：2020，申请号：CN202010014220 .5

7.师进生，杨曼丽，王丽丽，孔晓颖。一种可降解的黑色素防紫外线保温透明薄，申请年份：2019，申请号：CN201911387531 .X

8.师进生，孔晓颖，郭业昌。一种微控释高效气体保鲜材料及其制备方法，申请年份：2018，申请号：CN201810425496 .5

指导学生参加创新创业项目或比赛

2023第九届山东省“互联网+”大学生创新创业大赛，省级银奖

2023 “建行杯”第九届山东省大学生科技创新大赛，省级三等奖

2022全国大学生生命科学(CULSC)竞赛，国家级三等奖

2022山东省第十三届“挑战杯”山东省大学生创业计划竞赛，省级银奖

2022第八届山东省“互联网+”大学生创新创业大赛，省级铜奖

指导国家级大学生创新立项3项，省级大学生创新立项2项，校级大学生创新立项5项

招生专业及联系方式

招生专业：医学技术-医学检验技术

所属基地：青岛大学再生医学与检验创新研究院

联系方式：kongxiaoying@qdu.edu.cn，13884966191