专家简介
马慧朋，女，博士，副教授，硕士研究生导师，卫生检验教研室副主任。2013年于中国科学院大连化学物理研究所生物技术部获博士学位。同年入职大连医科大学检验医学院，从事微流控芯片在生物医学方面的基础研究工作。2017作为高级访问学者赴澳大利亚迪肯大学进行交流活动。主持一项国家级课题、多项省市级课题。近年来，以第一作者或通讯作者发表英文SCI学术论文20余篇，申请多项发明专利，授权发明专利一项。
研究方向
基于微流控芯片技术构建仿生肿瘤微环境平台，通过三维共培养模拟体内肿瘤生长状态及细胞间互作，精准重现肿瘤特征。以此为基础，深入探索中药活性成分对肿瘤微环境的调控机制，为肿瘤治疗新靶点的开发及中药现代化研究提供可靠的技术平台与理论依据。
在研项目
1.国家自然科学基金青年项目，81601825，基于微流控芯片的转移性乳腺癌CTCs的检测及其功能研究，18万元，主持
2.辽宁省科技厅博士启动项目，201601237，基于微流控芯片技术的三维肿瘤细胞侵袭动力学研究，5万元，主持
3.辽宁省教育厅科学研究一般项目，L2015150，微流控芯片3D肿瘤细胞EMT平台的构建及初步应用，3万元，主持
4.辽宁省教育厅科学研究一般项目，LZ2020017，ESIPT型荧光探针识别机理研究及其应用，3万元，主持
5. 大连市高层次人才创新支持计划，三维数控芯片用于全血CTCs的筛选及效能评价2018RQ30，10万元，主持
代表性文章（第一或通讯作者）
Shuxuan Jin, Qian Wu, Shiqi Chang, Shaojiang Zeng, Jiqiu Yin,Huipeng Ma*. Study of the Reciprocal Interaction Between Tumor Cells and Macrophages Based on the Biomimic Microfluidic Device. Electrophoresis, 2025; 0:1–9 Qian Wu, Shuxuan Jin, Shiqi Chang, Shuang Xu, Zhiping Xu, Shaojiang Zeng, Xiaohua Huang,Huipeng Ma*. Matrix-free microfluidic 3D biomimetic chip for identifying type I collagen on doxorubicin treated MDA-MB-231 cell. Microfluidics and Nanofluidics, 2025, 29:49 Jin-Dou Huang, Zhixin Duan, Feng Lin, Shibo Cheng, andHuipeng Ma*.Theoretical Study on Optoelectronic Properties of 1,4-Dithiazole-5,10-dihydrophenazine and Its B ← N‑Fused Derivatives. J. Phys. Chem. A 2024, 128, 6474−6481 Jin-Dou Huang, Feng Lin, Shibo Cheng,Huipeng Ma*. Theoretical Insights into the Luminescence and Sensing Mechanisms of N,N’‑Bis(salicylidene)-[2-(3’,4’-diaminophenyl)benzthiazole] for Copper(II). The Journal of Physical Chemistry A. 2023, 127, 966−972 Shiqi Chang, JingWen, Yue Su,Huipeng Ma*. Microfluidic platform for studying the anti-cancer effect of ursolic acid on tumor spheroid. Electrophoresis 2022,43,1466–1475 Jin-Dou Huang, Shibo Cheng, Wenliang Li, Feng Lin,Huipeng Ma*, Bin Dong*. Fluorescence enhancement mechanism of thymolphthalein-based probe by coordination interaction with zinc ion. Journal of Molecular Liquids, 2021, 339, 116275. Yanyu Dong#, Wenping Sun#, Shiqi Chang, Tong Li, Xiaohua Huang, Shanghua Xing, Tianyu Bai,* andHuipeng Ma*. A Fluorescent Turn-on Probe Based on Zn-doped AgIn5S8 Quantum Dots for Imaging of Hydrogen Sulfide in Living Cells. Chemistry Select, 2020, 5, 13545–13549 Dengyi Chen, Jing Wen, Shaojiang Zeng,Huipeng Ma*.DNA fragment-assisted microfluidic chip for capture and release of circulating tumor cells. Electrophoresis 2019, 40, 2845–2852 Huipeng Ma, Cuicui Sun, Gerilehu Xue, Guanlin Wu, Xiaohan Zhang, Xu Han, Xiaohui Qi, Xia Lv,Huijun Sun, Jianbin Zhang. Facile synthesis of fluorescent carbon dots fromPrunus cerasiferafruits for fluorescent ink, Fe3+ion detection and cell imaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. (2019) 281–287 (2.84) Hui-Peng Ma,Xue Deng, Deng-Yi Chen, Di Zhu, Jin-Ling Tong, Ting Zhao, Jin-Hui Ma and Yan-Qiu Liu. A microfluidic chip-based co-culture of fibroblast-like synoviocytes with osteoblasts and osteoclasts to test bone erosion and drug evaluation. R. Soc.open sci.2018, 5: 180528 (2.504)
招生专业
临床检验诊断学、医学技术
在读研究生情况
硕士研究生6人
联系方式
电子邮箱：huipeng_ma@126.com
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