博士，硕士研究生导师，副主任技师，大连医科大学附属第二医院检验科

主要研究方向：

糖生物学与肿瘤免疫：通过糖生物学、分子免疫学、肿瘤学等学科研究核心岩藻糖基化对肿瘤免疫的影响

主持课题：

（1）辽宁省科学技术厅,博士启动基金, 2022-BS-254, Fut8对细胞毒性T淋巴细胞PD-1表达调控的机制研究, 2022-08至2024-08, 3万元,在研

（2）大连市卫生健康委员会，大连市医学科学研究计划项目，2012026，Fut8基因敲除抑制乌拉坦诱导小鼠肺腺癌形成机制研究，2020.11-2022.11，2万元，结题

代表性研究成果（第一作者）

1. Zhang Y^#,Zhang N^#, Song W, Yousuf S, Li W. Ablation of the GDP-fucose transporter suppresses lung cancer cell proliferation and migration by reducing expression of PD-L1. Journal of Cancer. 2023;14(17):3295-308.

2.Zhang NZ, Zhao LF, Zhang Q, Fang H, Song WL, Li WZ, et al. Core fucosylation and its roles in gastrointestinal glycoimmunology. World journal of gastrointestinal oncology. 2023;15(7):1119-34.

3. Zahid D^#,Zhang N^#, Fang H, Gu J, Li M, Li W. Loss of core fucosylation suppressed the humoral immune response in Salmonella typhimurium infected mice. Journal of microbiology, immunology, and infection. 2021;54(4):606-15.

4.Zhang N^#, Li M^#, Xu X, Zhang Y, Liu Y, Zhao M, et al. Loss of core fucosylation enhances the anticancer activity of cytotoxic T lymphocytes by increasing PD-1 degradation. European journal of immunology. 2020;50(11):1820-33.

5. Li Z^#,Zhang N^#, Hui F, Zahid D, Zheng W, Xu X, et al. FoxO1 controls the expansion of pre-B cells by regulating the expression of interleukin 7 receptor α chain and its signal pathway. Immunology letters. 2019;216:28-35.

6.Zhang N^#, Liu L^#, Fan N, Zhang Q, Wang W, Zheng M, et al. The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation. Oncotarget. 2016;7(38):61587-600.

专利：

李文哲;张念竹;李明;王若雨;王文宇;丁宝龙;李雪滢;一种核心岩藻糖基转移酶的抑制剂及其应用, 2023-9-12,中国, ZL 2022 1 0069323.0

招生专业：

临床检验诊断学

联系方式：

zhangnianzhu2020@163.com